View abstract. View abstract. View abstract. If you are experiencing serious medical symptoms, please see the View abstract. Take extra care if you are taking drugs to help with your thyroid. Hidese S, Ogawa S, Ota M, et al. IV. The best time to take ashwagandha is at the time that works best for you. Mixing tyramine and MAOI antidepressants can result in headache, nausea, anxiety, dangerously high blood pressure and even hemorrhagic stroke. Complement Ther Med. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. According to the NIH, ashwagandha may interact with certain prescription medications, including antidiabetes drugs, antihypertensive drugs, immunosuppressants, benzodiazepines, certain sedative . It is commonly used for stress. Ashwagandha can interact with diabetes, blood pressure, and immunosuppressant medications. J Diet Suppl. 2020;12(2):e7083. The herb has been proven to interact with many other drugs, the interaction with SSRI (selective serotonin reuptake inhibitor) or Benzodiazepines are not proven scientifically. Naturopathic care for anxiety: a randomized controlled trial ISRC TN78958974. Indian J Exp Biol. Is Fish Oil Dangerous With Antidepressants? However, the review noted various limitations of the studies, including study design and potential bias. WebMD does not provide medical advice, diagnosis or treatment. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Investigation of CYP2B6, 3A4 and -esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. View abstract. Indian J Physiol Pharmacol. There aren't any specific antidiabetic drugs ashwagandha is known to interact with. Can You Take A Z-Pak If You Have A Penicillin Allergy? Drug-induced hepatocellular injury due to herbal supplement ashwagandha. Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. A total of 203 drugs are known to interact with levothyroxine . Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. 2012;10(1):48-9. View abstract. When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. hydrochlorothiazide, spironolactone, chlorthalidone). Phytomedicine 2000;7(6):463-469. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? Doses higher than that may interact with lexapro, or produce more pronounced effects. View abstract. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. How to use To use ashwagandha products safely, people must always follow the dosage advice given by the manufacturer. According to a December 2012 study in the Journal of Medicine and Life, SSRIs are primarily the recommended treatment for depression. Who Shouldn't Take Ashwagandha? Some evidence suggests that ashwagandha may interact with: Before starting a new supplement, it is vital that you carefully read the ingredients list and nutrition facts panel to know which ingredients and how much of each ingredient is included in the supplement. 2017;14(6):599-612. doi:10.1080/19390211.2017.1284970, Tiwari S, Gupta SK, Pathak AK. Overall, ashwagandha doesn't seem to have many reported significant drug interactions. We can, however, make some educated guesses on drug interactions based on ashwagandha works, and the effects it is known to have. Lower ashwagandha doses of 225 milligrams per day to 400 milligrams per day have been associated with perceived improvements in stress and anxiety. While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. Take extra care if you are using drugs to help you relax or sleep. Front Pharmacol 2022;13:901710. Immunopharmacol.Immunotoxicol. Ashwagandha is considered safe when taken daily for up to three months. Is it safe to take ashwagandha every day? Curr Res Toxicol. From the study results, researchers concluded that ashwagandha improved memory and focus. Ashwagandha supplements come in various forms, including capsules, gummies, caplets, liquid extracts, and powders. View abstract. Often, herbs and supplements come with a risk of side effects. 2020;72:28-36. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Afewerky HK, Ayodeji AE, Tiamiyu BB, et al. Can I Take Lexapro & Vitamin Supplements? Complement Ther Med 2016 Aug;27:25-9.View abstract. Avoid beer, wine, and mixed drinks (alcohol) while taking this product. Therefore, it should be used cautiously with drugs used to treat diabetes, including: Just like with potential interactions between ashwagandha and diabetes drugs, there may be a potential issue with drugs used to treat high blood pressure as studies show ashwagandha mayhave blood-pressure-lowering effects. In our latest question and answer, the pharmacist discusses whether or not ashwagandha supplements interact with prescription drugs. Expert Rev Clin Pharmacol. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Additionally, ashwagandha may increase testosterone levels in the body. 2008;6:14. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Sedatives: Since ashwagandha can both energize and induce restorative sleep, it might negate or amplify the effect of other sedative drugs, especially the benzodiazepines. root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. This product can contain high amounts of iron. After 30 days, those who took either dose of ashwagandha self-reported positive effects on their anxiety. View abstract. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. blood glucose). According to their lab study, withanone may interfere with DNA, leading to liver damage. Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. Do not use this product if you are pregnant or plan to become pregnant soon. It may cause you to become sleepy or drowsy. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. It's much more likely for certain foods, like grapefruit juice or herbal supplements, to affect antidepressant function. Drugs that cause sleepiness and drowsiness are called sedatives. In rare cases, ashwagandha may cause liver damage. View abstract. J R Coll Physicians Edinb. Ashwagandha may lower blood sugar (i.e. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. It is also important to note that ashwagandha may interact with certain medications, such as immunosuppressants and sedatives. ; Vomiting and nausea. View abstract. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Another study (a systematic review and meta-analysis) found that ashwagandha may benefit athletes. PLoS One 2021;16(9):e0257843. Some ontologies are recognized by everyone, diabetes insipidus medication side effects and some are recognized noni lower blood sugar as ontologies only by . Per the review, five people experienced liver toxicity after taking varying brands and doses of ashwagandha for different lengths of time. Indian J Psychol Med. Lousewort - Amiloride, Hydrochlorothiazide, Cassia Cinnamon - Aspirin, Butalbital, Caffeine, Abuta - Bismuth Subcarbonate, Calcium Carbonate, Opium, English Adder's Tongue - Inotuzumab Ozogamicin, Patricia Kane (pk) Protocol - Indomethacin, Pulsed Electromagnetic Field (pemf) Therapy - Cabozantinib. In fact, according to the book Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, published in 2010 by the British Psychological Society, there are no specific vitamins contraindicated for consumption with antidepressants. Nevertheless, be sure to talk to your doctor before adding on ashwagandha to blood pressure medicine, such as: Ashwagandha might increase the effects and adverse effects of thyroid hormone drugs. View abstract. Ashwagandha may increase thyroid hormone levels. Still, a seal of approval from one of these agencies is your best bet for supplement quality since dietary supplements and herbs are not regulated in the United States. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. All rights reserved. Pharmacol Biochem.Behav 2003;75(3):547-555. All rights reserved. 2017 Jan;22(1):96-106 View abstract. This is called a medicine interaction. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! PLoS One. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. Sleep Sci. Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A. For example, it may increase the sedative effect of medications that treat anxiety and insomnia. Memorial Sloan-Kettering Cancer Center: Ashwagandha, NYU Langone Medical Center: Ashwagandha Interactions You Should Know About, NYU Langone Medical Center: Benzodiazepines, "Therapeutic Drug Monitoring"; Herbal Supplements and Therapeutic Drug Monitoring; A. Dasgupta; April 2008, University of Maryland Medical Center: Anaphylaxis. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. This information does not endorse any treatments or medications as safe, effective, or approved for treating a . 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Last updated Apr 30, 2023 Key points Ashwagandha has not been well studied in regard to potential interactions with prescription medication. drugs for diabetes and blood pressure). The specific components of physical performance included strength and power, endurance, and fatigue/recovery. PLoS One 2009;4:e6628. Herbal supplements, like St. John's wort or garcinia cambogia, are much more likely to affect the functionality of your antidepressants compared to vitamins or mineral tablets. 1996;35(1):95-100. These severity listings are for informational use only. Indian J Exp Biol. These are: In addition to these commonly prescribed antidepressants, there are other central nervous system drugs with antidepressant effects, like antipsychotics, as well as herbs and supplements that have natural antidepressant properties. Moderate 623 Interactions; Unknown 2123 Interactions; Interaction Rating Key. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. View abstract. There is concern that ashwagandha interacts with anesthesia commonly used in surgery. Evaluation of the efficacy of withania somnifera (ashwagandha) root extract in patients with obsessive-compulsive disorder: a randomized double-blind placebo-controlled trial. Some don't work well with prescription medicines. J Res Ayur Sid 1980;1:370-385. J Med Food 2022. Is It Safe To Take Keflex (Cephalexin) With Birth Control? Read more: How Vegans Can Get All Their Nutrients (Without Taking Supplements). In Ayurvedic medicine, ashwagandha has been used for centuries as an alternative treatment for anxiety. View abstract. They should also be kept from direct sunlight and stored in their original bottle or container. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. The length of use of ashwagandha ranged from 14 to 110 days, and doses ranged from 450 milligrams to 1,350 milligrams per day. Levothyroxine is used to treat the following conditions: Hashimoto's disease. low blood sugar). Twelve studies were included in the final review, and researchers concluded that ashwagandha showed more improvements in physical performance than placebo pills. Serotonin syndrome can even result in death. 2022;13(2):100510. doi:10.1016/j.jaim.2021.08.003, Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Ancient herb eases stress, boosts memory, and may help you lose weight. View abstract. Hypothyroidism, After Thyroid Removal. Supplements That Are Similar to Ashwagandha. Of the 58 participants in the study, those who took ashwagandha had reduced levels of cortisol (a stress hormone) as well as lower perceived stress scores by the end of the eight-week study. It may also interact with other herbs, supplements, and even foods. 1988;26(11):877-882. This is because ashwagandha is thought to be an adaptogen, a substance that may help the body resist stress. Effect of Ashwagandha (Withania somnifera Dunal) on the process of ageing on human volunteers. Acta Nerv Super 1990;32(1):1-5. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. Lu, L., Liu, Y., Zhu, W., Shi, J., Liu, Y., Ling, W., and Kosten, T. R. Traditional medicine in the treatment of drug addiction. Phytother Res 2022. Cancer Lett. Xanax is in the drug class benzodiazepines. View abstract. 8-19-2005;334(1):276-287. Hence, be cautious if taking these medications and want to take Ashwagandha also. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Nutrients. There are a variety of vitamins and minerals that are essential for good health. Ashwagandha might cause sleepiness and slowed breathing. 1965;9(3):127-136. 2012;34(3):255-62. View abstract. View abstract. Melissa Nieves, LND, RD, is a registered dietitian and licensed nutritionist who works as a bilingual telehealth dietitian. Mandlik Ingawale DS, Namdeo AG. Chronic stress increases cortisol levels, leading to lower levels of T3 and T4. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. View abstract. What to Look for When Choosing Ashwagandha Supplements, Uses of Lavender: Everything You Need to Know, I Tried Taking Ashwagandha and It Gave Me Crazy Vivid Dreams, Natural withanolides in the treatment of chronic diseases, Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects, Potential clinical applications of Ashwagandha (, Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study, An investigation into the stress-relieving and pharmacological actions of an ashwagandha (, An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (, Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study, A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (, Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers, Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network, DNA damage by withanone as a potential cause of liver toxicity observed for herbal products of, Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial, Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency, Vitamin E, turmeric and saffron in treatment of Alzheimer's disease, Tart cherry juice in athletes: a literature review and commentary, Dietary supplements: what you need to know. Gastrointestinal side effects including nausea, vomiting and diarrhoea. J Ethnopharmacol. Ashwagandha's leaves contain a compound that causes sleep induction and is used for treating insomnia. Phytother.Res 2010;24(1):129-135. Be sure to let your doctor know if you plan on adding ashwagandha to your medication list so you can be appropriately monitored. In 2020 and 2021, some people began using ashwagandha to diminish the harmful effects of COVID-19, although there is no evidence to support that use. Change in balance, feeling shaky, or unsteady, Not able to think clearly or change in thinking, US Department of Defense Dietary Supplement Resource, https://www.opss.org/article/ashwagandha-dietary-supplement-products, This generalized information is a limited summary of diagnosis, treatment, and/or medication information. According to one study that examined ashwagandha's effect on athletics, ashwagandha may improve both endurance and recovery in healthy adult athletes. Researchers from a different study believe that withanone (Win), a bioactive substance found in ashwagandha, is to blame for the liver damage. A November 2013 study in the Open Neurology Journal found that vitamin B12 could also help reduce symptoms of depression, while a March 2015 study in the Australian Journal of Herbal Medicine found that several B-complex vitamins could help reduce depressive symptoms. However, scientific evidence supporting these and other uses is poor. One systematic review found just five human trials that studied ashwagandha as an anxiety treatment. Information from this source is evidence-based and objective, and without commercial influence. View abstract. Ghosal S, Lal J, Srivastava R, and et al. Varying levels of research have looked at the potential benefits of ashwagandha. You should also review supplement labels with a healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. When multiple foods or supplements are processed by your body via the same exact route, they may compete with one another. You can also connect with Dr. Brian Staiger on LinkedIn. These include drugs like thyroid desiccated, levothyroxine, or liotrix. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Be aware that antidepressants and vitamins typically work with each other the vitamins won't replace your medication. Cent.Nerv.Syst.Agents Med.Chem. Do note that ashwagandha itself does not . Mental health statistics show between 3 and 5 percent of adults live with a depressive disorder globally, according to a January 2014 study in Depression and Anxiety. Kuppurajan K, Rajagopalan SS, Sitoraman R, and et al. Indian J Exp Biol 2000;38:607-9. Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. View abstract. Ashwagandha appears to stimulate your endocrine system . Studies are inconclusive, but ashwagandha may have immune-stimulating properties. In the study, participants received either a placebo or 600 milligrams per day of ashwagandha for eight weeks. Verywell Health's content is for informational and educational purposes only. Ashwaganda is used to treat Herbal Supplementation. A recent study looked at the health claims and safety of ashwagandha and found that the herb has shown anticancer, anti-inflammatory, heart-protective, liver-protective, and immunomodulatory (able to change the immune system) actions. View abstract. A recent study out of India compared varying doses of ashwagandha to a placebo for the treatment of stress. Ashwagandha can react with certain medications and supplements you may already take, and result in adverse effects. 2021 Nov 30;2021:8254344. If you consume something that isn't recommended, you could end up reducing the effectiveness of your medication or increasing the likelihood of side effects. Nutrients. This information may not fit your specific health circumstances. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects.
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